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Zeiss

LSM 880

Zeiss LSM 880 family
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The Zeiss LSM 880 is a confocal laser scanning microscope designed for fluorescence imaging of fixed and live samples. The Zeiss LSM 880 features a 32-channel GaAsP Airyscan detector for high-resolution imaging with spectral detection. The Zeiss LSM 880 supports laser lines at 405 nm, 458/488/514 nm, 561 nm, and 633 nm, with additional lines for ablation and photoactivation.[1][2][3]

LSM 880 — Inventory photo
Fig. 01LSM 880Inventory photo[4]

What it is

The LSM 880 is an inverted confocal microscope with Airyscan. The system uses a Quasar module scanhead with a 32-channel GaAsP detector and two flanking multialkali PMTs.[2][1]

How it works

The LSM 880 is controlled by the ZEN software (black edition). The system includes a set of laser lines: 405 nm (30 mW), multiline 458/488/514 nm (25 mW), 561 nm (20 mW), and 633 nm (5 mW). Detectors comprise two photomultiplier tubes, one GaAsP detector, and the Airyscan detector (32 GaAsP). The Airyscan detector improves resolution and signal-to-noise ratio.[3][1]

Where it fits in the process flow

The system can acquire stacks of optical sections for three-dimensional visualization and supports multidimensional acquisition modes including Z-stacks, time series, tile scans, and position lists.[2][5]

Applications

The system supports applications such as fixed-sample imaging, live-cell time-lapse experiments, and three-dimensional reconstruction. The Airyscan module provides enhanced resolution suitable for quantitative live-cell experiments. The 32-channel spectral detector allows simultaneous acquisition and on-the-fly unmixing of multiple fluorophores.[1][3]

What do the numbers mean?

Power & electrical1

Computer System
2x Intel Xeon E5-2623 v3 3.0 GHz, 64GB DDR4-2133 MHz ECC RAM, 4x 2TB RAID 10, NVIDIA Quadro K2200 4GB, Windows 7 Ultimate Embedded x64[3]
Accurate?

Optics & imaging9

Laser Line 405 nm
30 mW[3]
Accurate?
Laser Line 458/488/514 nm
25 mW multi-line[3]
Accurate?
Laser Line 561 nm
20 mW[3]
Accurate?
Laser Line 633 nm
5 mW[3]
Accurate?
Additional Laser Lines
HeNe 594 nm, pulsed 405 nm and 440 nm[1]
Accurate?
Detectors
2 PMT, 1 GaAsP, 1 Airyscan (32 GaAsP)[3]
Accurate?
Frame Rate
19 frames per second at 512 x 512 pixel resolution[3]
Accurate?
Objectives
LD C-Apochromat 40x/1.1 W Corr, Plan-APOCHROMAT 100x/1.4 Oil Ph3, Plan-Apochromat 40x/1.3 and 63x/1.4 Oil DIC, Plan-Apochromat 20x/0.8 WD=0.55, Plan-Apochromat 10x/0.45 WD=2.0[1]
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Scanhead
Quasar module with 32-channel GaAsP detector and two flanking multialkali PMTs[1]
Accurate?

Control & software1

Software
Zeiss Zen 2.3 (Black Edition)[3]
Accurate?

Vintage & configurations

Documented models & variants

DesignationGenerationVintageChangesSource
LSM 880 NLO———manualslib.com[5]
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What does it need to run?

Site utility requirements, footprint, and infrastructure needed to install and operate this tool. Sourced from public records.

  • Computer System2x Intel Xeon E5-2623 v3 3.0 GHz, 64GB DDR4-2133 MHz ECC RAM, 4x 2TB RAID 10, NVIDIA Quadro K2200 4GB, Windows 7 Ultimate Embedded x64[3]

Where are the manuals?

Generated from public-source data on file. Enter your email to access — nothing is published; details are routed privately.

Not publicly documented

Field notes

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Frequently asked questions

What laser wavelengths are available on the LSM 880?

The LSM 880 is equipped with laser lines at 405 nm (30 mW), a multiline argon laser (458/488/514 nm, 25 mW), 561 nm (20 mW), and 633 nm (5 mW).[3]

What is the maximum frame rate of the LSM 880?

The LSM 880 can achieve 19 frames per second at a 512 x 512 pixel image resolution.[3]

Does the LSM 880 support Airyscan?

Yes, the LSM 880 can be configured with the Airyscan detector module and supports Airyscan imaging modes, which improve resolution and signal-to-noise ratio.[2][3][1]

Not publicly documented

The following facts about the LSM 880 are absent from this record as of this revision. First-hand knowledge or a citation closes a gap; every submission is reviewed before publication.

  • No publicly documented production dates or lifecycle milestones (introduction, end of production, EOL) for the LSM 880 are on record.

    Answerable by: OEM historical records or a trade-press announcement

  • The control-system platform and OS era of the LSM 880 are not on record.

    Answerable by: an engineer who operated it or OEM installation records

  • No publicly documented failure modes or field errata for the LSM 880 are on record.

    Answerable by: a field service engineer, process engineer, or maintenance technician

  • The process node or technology generation of the LSM 880 is not on record.

    Answerable by: an OEM datasheet or a fab qualification report

  • No publicly documented compatible parts, consumables, or accessories for the LSM 880 are on record.

    Answerable by: an OEM parts catalog or a service engineer

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Sources & citations

Sources (5)Every fact above is drawn from these public sources
  1. [1]biomedcorefacilities.brown.edu — biomedcorefacilities.brown.edubiomedcorefacilities.brown.edu
  2. [2]ZEISS LSM 880 USER MANUAL Pdf Download | ManualsLib — manualslib.commanualslib.com
  3. [3]manualslib.com — manualslib.commanualslib.com
  4. [4]Inventory photo
  5. [5]manualslib.com — manualslib.commanualslib.com
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Last updated Oct 1, 2026.

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